"Sweet Jane" (The Velvet Underground)

"Accessible" isn't a word that one uses when talking about The Velvet Underground.  Lou Reed & Co. never aimed for the mainstream.  Gutters, alleyways, and anywhere where the light was dim—that was more their territory.
However, after years of not selling any records, the band made an attempt at a pop album called Loaded (1970).  On it, is the track "Sweet Jane," perhaps Reed's most effervescent, accessible composition of all time.  Unlike a lot of songs in the band's catalog, you don't really have to get acclimated to "Sweet Jane" before it reveals its charms.  It hits you in the gut from moment one with its lean, mean riff, which lets you know it's destined for rock & roll immortality the moment you hear it.  (It's my personal favorite Reed riff, edging out "I'm Waiting for the Man" by a hair.)  
Nevertheless, Reed can't help himself from getting a little gritty, throwing in the suggestion that seemingly buttoned-up protagonists of the song, Jack and Jane, like to try on each other's clothes  (Jack's in his corset / Jane is in her vest).  To me, it was his way of pointing out that the mainstream is just as freaky as the fringe, even though outward appearances might lead you to believe otherwise.