"Crosseyed and Painless" (Talking Heads)

There was no band in quite the same league as Talking Heads from 1977 to about 1984.  If you've never seen it, watch the concert film Stop Making Sense (1984).  Fair warning: if you don't already own every album in the band's discography before watching the film, you will purchase every album subsequently.  (It's worth your bank account taking a hit and you having to eat Ramen for a few weeks.  Trust me.)
My favorite Talking Heads album, Remain In Light (1980), falls smack-dab in the middle of that golden period of output.  The album is a non-stop tour de force of memorable melodies, polyrhythmic percussion, highly abstract yet highly literate lyrics, and producer Brian Eno's experimental sampling and tape loops.  It sounded like nothing else in 1981, and it still sounds otherworldly today.
Although it's difficult to pick out individual faves from the album, "Crosseyed and Painless" is a track that definitely shines.  The song is built around an Afrobeat rhythm, with cowbells and various percussion loops creating this undulating groove behind Chris Frantz's relentless drums and Tina Weymouth's gulps and slaps of fat bass.  (Side note: that woman must have callouses on her thumbs the size of grapes.)  It also features a guest spot by King Crimson guitarist Adrian Belew, who releases a buzzbomb guitar attack in the middle of the song.  (It's not a showboating type of guitar solo; nevertheless, it soars and wails in all the right places.)
Then there's frontman David Byrne's characteristically nervous vocals and a somewhat surprising "rap" at the end of the song (Facts are simple and facts are straight / Facts are lazy and facts are late...), which was inspired by Kurtis Blow's "The Breaks" (1980).
The song was released at the time as a promotional single with an accompanying video by choreographer Toni Basil (of one-hit-wonder "Mickey" fame), who used a Fresno, CA-based breakdance troupe known as Electric Boogaloos for the shoot.  I remember seeing the video ONCE on MTV2 sometime in the late 90s at like 2 am, and I didn't want it to end; it was like being zapped back to my childhood. 
I finally found the original video again on the interwebs for your (and my) enjoyment.
(P.S.  Dig the guy doing the moonwalk--a.k.a. the "backslide"--at the 3:30 mark, almost three years before Michael Jackson "debuted" it on the Motown 25 TV special!)